The exponential influx of scientific research on melatonin is associated with a greater orientation towards the study of the systemic effects of melatonin and their derivatives, as well as their clinical implications. Proof of this fact is summarized in the present compilation, where melatonin is presented as a remarkable agent to counteract most of the physiopathological events that trigger several disorders. The book also collects evidence about melatonin's interactions with two high-affinity G protein-coupled receptors to provide new pharmacological targets for the treatment of cancer,...