Coronavirus disease 2019 (COVID-19) is a respiratory illness that can spread from person to person. The virus that causes COVID-19 is a novel coronavirus that was first identified during an investigation into an outbreak in Wuhan, China. Chapters 1-16 contain information about the science behind the virus, economic implications, global response and public safety. Chapters 17 and 18 access the readiness of the United States Public Health System in response to emerging infectious diseases, pandemics and biological attacks.