This volume contains the proceedings of the conference on Lie Algebras, Vertex Operator Algebras, and Related Topics, celebrating the 70th birthday of James Lepowsky and Robert Wilson, held from August 14-18, 2015, at the University of Notre Dame, Notre Dame, Indiana. Since their seminal work in the 1970s, Lepowsky and Wilson, their collaborators, their students, and those inspired by their work, have developed an amazing body of work intertwining the fields of Lie algebras, vertex algebras, number theory, theoretical physics, quantum groups, the representation theory of finite simple...