Caenorhabditis elegans An Overview and Emerging Roles in Studying Disease explores different disease models that have been successfully validated in this nematode, either to unravel disease mechanisms or to perform drug screenings. This nonpathogenic organism has helped to firstly identify genetic mechanisms important in cancer (Ras and Bcl oncogene signaling), aging (insulin signaling), and nervous system development (UNC-6/Netrin signaling). Human conditions such as aging/frailty (Chapter One), metabolic syndrome (Chapter Two), neurodegenerative diseases (Chapters Three and Four) and...