The topic of rationality is treated in a perspective thatintegrates elements of philosophy of language, ratiovitalism, phenomenology, pragmatism, and philosophy of life. The approach is inspired by Ortega y Gasset and Wittgenstein. The contributions focus on: dynamics of belief and knowledge, the role of world-pictures and forms of life, questions regarding certainty, ignorance, doubt, and madness, as well as matters of pluralism and relativism.