This volume contains the proceedings of the First International Con- rence on Complex System Design & Management (CSDM 2010; website: http: //www.csdm2010.csdm.fr). Jointly organized, under the guidance of the CESAMES nonpro't organization, by Ecole Polytechnique and Ecole Centrale de Paris, it was held from October 27 to October 29 at the Cit e Internationale Universitaire of Paris (France). Mastering complex systems requires the understanding of industrial pr- tices as well as sophisticated theoretical techniques and tools. Thus, the c-...