There are many clinical and experimental evidences indicating the involvement of oxidative stress in pathogenesis of diabetes mellitus and its complications. Increased oxidative stress is due to excessive reactive oxygen species generation due to persistent hyperglycemia and a sharp reduction of antioxidants defenses and the tissue antioxidant status. An imbalance between oxidative stress and antioxidative defense mechanisms in diabetics can result in cell and tissue damage and accelerate diabetic complications. There is mounting evidence that a general increase in antioxidant...