This volume contains the proceedings of the 11th International Symposium on Orthogonal Polynomials, Special Functions, and their Applications, held August 29-September 2, 2011, at the Universidad Carlos III de Madrid in Leganes, Spain. The papers cover asymptotic properties of polynomials on curves of the complex plane, universality behavior of sequences of orthogonal polynomials for large classes of measures and its application in random matrix theory, the Riemann-Hilbert approach in the study of Pade approximation and asymptotics of orthogonal polynomials, quantum walks and CMV matrices,...