An actinide dependent shadow biosphere of archaea and viroids in disease states is described with archaeal digoxin playing a pathological role.Archaeal digoxin can produce neuro-immuno-endocrine-genetic-metabolic integration. Archaeal digoxin by producing sodium-potassium ATPase inhibition can generate synchronised sustained burst activity in neuronal cells resulting in aelectromagnetic field and a plasma state in the cell. This can generate cellular and molecular electromagnetic traces important in signal transduction and quantal perception. Metal actinides in beach sands have been...