The aim of the work is to evaluate the transdermal potential of novel vesicular carrier, ethosomes, bearing aceclofenac, Non-steroidal anti-inflammatory drugs having limited transdermal permeation. Aceclofenac loaded ethosomal carriers were prepared, optimized and characterized for vesicular shape and surface morphology, scanning electronic microscopy, vesicular size, entrapment efficiency, stability, in- vitro release study.The formulation having 3% phospholipids content and 40% ethanol showing the grater entrapment and optimal average vesicle size of formulation was determine by Malvern...

The aim of this study was to develop a lipid based formulation for a poorly soluble drug belonging to BCS Class II. The intention of the formulation design was to develop a "self eroding matrix system" made of lipidic excipients which would release the drug mainly by the mechanism of erosion. To attain such as system, lipidic excipients like stearic acid and hydrogenated castor oil were used as matrix formers and surfactants like sodium lauryl sulphate and gelucire 44/14 were used as matrix modifiers. The formulations prepared were subjected to physicochemical and in vitro dissolution and...