The lives of massive galaxies are affected by many key processes, including gas accretion and star formation, feedback and quenching, black hole growth, mass assembly, galaxy mergers and interactions, chemical enrichment and stellar populations, dark matter, galaxy haloes, and satellite accretion. These proceedings of IAU Symposium 295 discuss recent progress in galaxy formation and evolution, and plan ahead for future challenges. They cover, from both theoretical and observational perspectives, the lives of massive galaxies from the formation of the first galaxies in the early Universe,...