This book LNCS 13547 constitutes the proceedings of the 14th International Symposium on Cyberspace Safety and Security, CSS 2022, held in Xi'an, China, in October 2022.The 26 revised full papers presented were carefully reviewed and selected from 104 initial submissions. The papers focus on Cyberspace Safety and Security, such as authentication, access control, availability, integrity, privacy, confidentiality, dependability and sustainability issues of cyberspace.