The opening chapter of this compilation extensively reviews scientific literature analyzing new molecular targets, ongoing research and future perspectives in the management of gastroenteropancreatic neuroendocrine neoplasms, a rare group of pathologically and clinically heterogeneous tumors. The significance of PI3K pathway components in lung cancer progression are highlighted, as well as possible therapeutic targets that can be explored in an effort to control the disease. Following this, the authors assess the contributions of flavin-containing monooxygenases 3 along with cytochrome P450...

Horizons in Cancer Research. Volume 75 analyses the strategic actions taken by the UK in the fight against cancer, reviewing the key investments and funding made available in the country. Following this, the authors discuss how efficient targeting of thioredoxin with compounds and proper knowledge of their mechanism of action may be an efficacious therapeutic intervention for cancer. This compilation goes on to xplore the otologic complications secondary to radiotherapy for nasopharyngeal cancer cases to provide a clinical perspective on this issue. An extensive review of the published...

In this compilation, an overview of recent achievements in clinical and biosensor technology in the diagnosis of acute lymphoblastic leukemia is provided. Various aptasensors such as optical, electrochemical and mass-sensitive are presented along with a novel approach for the recognition of cancer markers by molecular imaging methods based on atomic force microscopy, single molecule force spectroscopy and topography and recognition imaging. The authors review the strategies used to screen potential antimelanoma drugs, especially those involved in evaluating drugs in cancer cell lines, in...

This compilation begins by discussing the common pediatric brain tumors, their key oncogenic drivers and signaling pathways. An update on the clinical trials against druggable targets is also provided. An outline of the metabolizing pathways in cancer and the mode of action of aerobic glycolysis in cancer cells is presented, also highlighting the roles of nanotechnology in energy-based cancer therapies. The authors review recent studies that characterize the specific mechanisms involved in mediating -tocotrienol reversal of epithelial-to mesenchymal transition in malignant breast cancer...

In Horizons in Cancer Research. Volume 76, the molecular drivers associated with prostate cancers at different stages which can be exploited as drug targets are discussed. This information will be useful for designing rational targeted therapeutic strategies for treatment of this disease. Following this, the authors discuss lung cancer early diagnosis with traditional and alternative approaches. In lung cancer, smoking exposure has been identified as the main causative agent in smokers. A critical appraisal of the different updated techniques in the mediastinal staging of lymph nodes in lung...

This compilation includes details about recent innovations in the field of cancer treatment as well as best practices for managing the disease in various forms. The first chapter deals with the potential anticancer properties of the plant Trigonella foenum-graecum, also known as fenugreek. Following this, the authors provide clinically relevant information on physical therapy for women with breast cancer as well as targeted therapy for metastatic triple-negative breast cancer. Then, the authors discuss the evolution of the field of systematic therapy for urothelial cancer, which ranges from...

This edited volume presents seven chapters detailing recent progress in the field of cancer research. Chapter One explores the application of robotic surgery to radical cystectomy, highlighting patient selection, surgical approach, perioperative and oncologic outcomes as well as some areas of controversy in the literature. Chapter Two describes the principles of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy procedures with its potential risks for patients and staff. Chapter Three discusses findings related to ISG15 and protein ISGylation, and their association with...

This volume presents some of the latest research surrounding cancer. Chapter One provides a background on the importance of magnesium homeostasis, reviews the pre-clinical and clinical studies using magnesium therapy for cisplatin-induced acute kidney injury, and proposes future investigations to improve the translatability of these results to cancer treatment. Chapter Two discusses various liquid biomarkers of ovarian cancer such as exosomes, cell free DNA, miRNAs, circulating tumor cells, secretory proteins and autoantibodies and their subsequent detection via various nanobiosensors....