This issue of Interventional Cardiology Clinics covers bypass graft lesions and thrombectomy. Expert authors review the most current information available about saphenous vein grafts, including distal embolic protection devices, drug eluting stents vs bare metal stents, management of complications, optimal stenting, and more. Adjunctive pharmacotherapy for thrombotic coronary lesions and thrombectomy devices in coronary intervention are also discussed. Keep up-to-the-minute with the latest developments in this important aspect of interventional cardiology practice.