Built from a set of twenty standard amino acids, Proteins, the most abundant biological macromolecules found in living cells have great structural and functional diversity. Initially synthesized as linear polypeptide chains, they are required to fold to their unique native formats to gain function. Losing track during the folding process, proteins may misfold and end up as aggregates, causing neurodegenerative disorders. This book provides an overview of the protein folding scenario, the models and theories proposed, and consequences of misfolding have been discussed The book also provides a...

Bovine alpha lactalbumin, the regulatory component of lactose synthase complex is an important milk protein. The genetic locus of the protein spans over 2.5 kbp,s on chromosome 5 and is comprised of four exons, encoding 123 residue long monomeric protein. The differential expression of this gene in various cattle species has been attributed to its genetic polymorphism, explaining the role of allelic variations in milk production. Based on these facts, we have screened three bovine breeds namely Holstein, Jersey and local indigenous breeds for allelic variations where we have seen some novel...