Large genome sequencing projects generate huge number of protein sequences in their primary structures that are difficult for conventional biological techniques to determine their corresponding 3D structures and hence their functions. In this book, a novel method for prediction of protein secondary structure has been proposed and implemented together with other known methods in this domain. A benchmark data set is used in training and testing the methods under the same hardware, platforms, and environments. The methods in this work have been discussed and presented in a comparative analysis...