The concept of "psoriatic march" proposes that chronic cutaneous inflammation leads to systemic inflammation that in conjunction with increased oxidative stress triggers a cascade of events including oxidative stress, dyslipidemia, endothelial dysfunction and insulin resistance leading to metabolic syndrome or its individual components and increased risk of cardiovascular complications in psoriatics. A rise in plasma lipid and lipoprotein levels with disturbances in oxidation of triglycerides and cholesterol levels, particularly low-density lipoprotein favors atherosclerotic plaque formation...
The concept of "psoriatic march" proposes that chronic cutaneous inflammation leads to systemic inflammation that in conjunction with increased oxidat...