Detection, quantification, and control of impurities in drug and drug products have become unambiguous necessities as per the new Regulatory guidelines, predominantly by the International Conference on Harmonization (ICH) recommends routine analysis of all impurities 0.1% level through suitable analytical methods. So, it was essential to determine the impurities present in Brinzolamide, Cilnidipine and Loteprednol to guarantee its purity, potency and safety in the pharmaceutical products.