Osteoarthritis of knee joint is the most common Musculoskeletal disorder now a days. It can lead to deformities and can damage quality of life. Modern science can not provide satisfactory results specially in Musculoskeletal diseases. The science of Ayurveda provides positive results and improve quality of life . Ayurveda oral medications, Rasayana therapies and Panchkarma procedures can heal and repair osteoarthritis related problems and modify day to day activities.