The rising prevalence of multi-drug resistant Gram-positive, Gram-negative bacteria and fungi continues to provide momentum for the search and development of novel antimicrobial agents active against these pathogens. In search of new bio-active molecule, the development of hybrid molecules through the combination of different pharmacophores in one frame may lead to compounds with interesting biological properties. The co-administration of the heterocyclic moieties, acting by different mechanisms may have a synergistic effect, resulting in a higher activity than each of the components. In the...