The principal objective of caries removal is to eliminate the infected and necrotic tissues and microorganisms that may cause a persistent inflammation and treatment failure. Thus, thorough removal of the infected dentin has a direct influence and impact on the clinical success of a restoration. A number of studies have demonstrated that the bacteria left in the dentin of a cavity due to any of the above mentioned infection sources could maintain their activities for a long time. Although cavity preparation is an operative procedure that attempts to remove all infected dentin prior to placing...

Aggressive periodontitis is periodontal destruction that is become clinically significant around adolescence or early adult hood. The disease has been classified as localized and generalized periodontitis. Microorganisms and immune defects have been implicated in the pathogenesis of the disease. We try in this book to investigate some immunological, microbial and biochemical changes in serum and saliva of selected patients.