Opioid addiction is a major public health problem and the need for new efficient therapies is immense.18-Methoxycoronaridine (18-MC), an iboga alkaloid congener, has been previously shown to reduce the self-administration of several drugs of abuse, including opioids.18-MC is a potent antagonist of alpha3beta4 nicotinic receptors and this now appears to be the primary mechanism of 18- MC's action in the brain. These nicotinic receptors are present in high densities in the nuclei of the habenulo-interpeduncular pathway but not in the mesolimbic pathway, known to be involved in drug...