Orthodontic tooth movement is a biologically driven process that extends beyond the periodontal ligament and alveolar bone to involve the dental pulp-a highly vascular and innervated tissue essential for tooth vitality. Despite decades of clinical use, the effects of orthodontic forces on pulpal health remain a subject of debate, with concerns ranging from transient circulatory disturbances to irreversible pulpal damage.This systematic review critically examines contemporary human in-vivo evidence on pulpal changes induced by orthodontic forces, integrating findings from clinical,...