Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by the degeneration of dopaminergic neurons in the striatum and the presence of Lewy bodies composed mainly of -synuclein. Sirtuin 2 (SIRT2), a class III histone deacetylase, is known to influence key cellular functions such as genome integrity, mitochondrial regulation, autophagy, and apoptosis. Increased SIRT2 expression in aging and PD models highlights its relevance as a potential therapeutic target. In this study, a set of Benzoxazole-based methanimine derivatives, (E)-1-Phenyl-N-(2-Phenyl)-1,3-benzoxazol-6-yl)...