Below is a condensed version of approximately 1,000 characters, preserving the core methodology, results, and implications:---This study examines the seismic response of reinforced concrete buildings with plan irregularities using an integrated framework that combines statistical analysis and machine learning. A comprehensive dataset covering four common irregular configurations (C, L, T, and I shapes) was analyzed using five plan irregularity ratios (L/B, L/B1, B/L2, B2/B, and L1/L) and key seismic response parameters, including base shear, storey drift, roof displacement, and roof...