One of the most widely cultivated crops in the world is grapevine knowing that about 77.8 million tons of grapes are produced worldwide each year with around 10,000 varieties in the world. Both of vine growing, pruning and winemaking generate a vast quantity of wastes and byproducts such as skin, seeds, and canes. The aim of the present work is the evaluation of phytochemical composition and in vitro biological activities, of four Algerian grape cane and seed cultivars (Fragola Nera from the hybrid Vitis vinifera-Vitis labrusca, and Cardinal, Red glob, Gros noir, and Sabel from Vitis...