A comprehensive guide on regenerative endodontics, covering its principles, techniques, biological mechanisms, clinical applications, challenges and future perspectives in dental tissue regeneration.Regenerative endodontics focuses on biologically restoring the pulp-dentin complex using stem cells, scaffolds, and growth factors. It aims to regenerate damaged tissues, promoting continued root development and pulp vitality. Techniques include cell-based approaches like stem cell transplantation, cell-free methods using bioactive molecules, and hybrid strategies. Scaffolds, such as hydrogels and...