This book explores the design, synthesis, spectroscopic characterisation, computational insights, and antimicrobial evaluation of novel acid-amine derivatives. It highlights the importance of amide-containing drugs, their synthesis through acid-amine coupling reactions, and the vital role of computational tools in modern drug discovery. The study utilised high-purity chemicals and advanced software to ensure reliable outcomes. Novel derivatives were successfully synthesised by coupling -COOH and -NH2 groups with reagents such as HATU, HBTU, SOCl2, and POCl , and characterised using ¹H NMR,...