Development of a Bioactive Nanocomposite Using 3D Printing for Bone Tissue Engineering Applications with Targeted Drug Delivery presents an in-depth exploration of innovative materials and advanced fabrication techniques for regenerative medicine. The book focuses on the design and synthesis of bioactive nanocomposites tailored for bone tissue repair, integrating the precision of 3D printing to achieve complex scaffold architectures. It examines the role of biocompatible polymers, ceramics, and nanoparticles in enhancing mechanical strength, osteoconductivity, and controlled degradation....

This book provides a comprehensive exploration of cutting-edge strategies in the diagnosis and treatment of HER2-positive brain metastases, a critical challenge in oncology. The book highlights the integration of molecular imaging, targeted drug delivery, nanomedicine, and personalized therapeutic approaches to improve patient survival and quality of life. It examines the biological mechanisms driving HER2 signaling in brain tumors, while emphasizing translational research and clinical applications of theranostic platforms. Multidisciplinary perspectives are presented, bridging oncology,...

The book explores the intersection of neuroscience, artificial intelligence, and chronomedicine in addressing complex brain diseases linked to circadian rhythm disruption. This book examines how AI-driven analytics and machine learning can decode biological rhythms, enabling the design of personalized therapeutic strategies for disorders such as Alzheimer's, Parkinson's, and other neurodegenerative conditions. It highlights innovative approaches including digital biomarkers, wearable monitoring, and computational modeling that support precision chronotherapy by aligning treatment schedules...

The book introduces an innovative approach to overcoming therapeutic resistance in one of the most aggressive brain cancers. This book explores how nanotechnology, exosome engineering, and targeted delivery systems can be combined to improve drug transport across the blood-brain barrier. It emphasizes the role of exosome-derived monoclonal antibodies and TfR-targeting ligands in enhancing specificity, stability, and therapeutic efficacy for glioblastoma treatment. The text integrates concepts from molecular biology, oncology, pharmacology, and bioengineering, providing a multidisciplinary...

This book explores advanced biomaterial strategies for tissue regeneration in dental and craniofacial applications. The book focuses on the design and fabrication of 3D-printed nanocomposite scaffolds capable of dual drug delivery to promote osteogenesis and angiogenesis simultaneously. Integrating insights from materials science, bioengineering, and clinical periodontology, it examines nanostructured polymers, growth factor release kinetics, and cellular responses in controlled regeneration. Readers are guided through preclinical studies, additive manufacturing methods, and translational...

This book presents an in-depth exploration of the molecular mechanisms underlying neuronal survival and repair after ischemic brain injury. Focusing on the purinergic P2X4 receptor, the book examines how selective small-molecule modulators can influence neuroinflammation, synaptic plasticity, and vascular remodeling in stroke recovery. It integrates experimental findings, pharmacological strategies, and translational perspectives to bridge basic neuroscience with clinical neurotherapeutics. Readers gain a comprehensive understanding of P2X4-mediated signaling pathways, neuroimmune...

This book introduces a groundbreaking AI-driven framework for rapid brain imaging assessment in acute neurological conditions such as stroke, traumatic injury, and hemorrhage. Combining deep learning, edge computing, and multimodal data fusion, ARIA-NET enables real-time decision support for emergency physicians and neurologists. The book explores the system's adaptive architecture, real-time optimization, and clinical workflow integration, offering both theoretical foundations and practical implementation strategies. Through case studies and algorithmic analysis, it highlights how...

Dieses Buch erforscht das revolutionäre Feld der RNA-basierten Therapeutika und konzentriert sich auf den wissenschaftlichen Weg von Nukleotiden zum Gen-Silencing durch small interfering RNA (siRNA). Es bietet eine umfassende Analyse der Mechanismen hinter der RNA-Interferenz, der Struktur-Funktions-Beziehung von siRNA-Molekülen und ihrer therapeutischen Anwendungen in der modernen Medizin. Anhand detaillierter Fallstudien von zugelassenen siRNA-Medikamenten wie Patisiran, Givosiran und Inclisiran zeigt das Buch den Weg von der Entdeckung im Labor bis zum klinischen Erfolg auf. Es befasst...