Introduction :the management of the post-operative pain of endodontic treatment is searched by dealing with many factors such as chemical, mechanical or microbial factors. Some verities can predict the susceptibility of patient to post endodontic pain (age, gender, preoperative pain) which enable the dentist to anticipate this pain. Objective: the aim of this systematic review is to give details about the characteristics of post endodontic pain and its therapy and to discuss the different factors of risk which influences postoperative pain and therapy quality. Materials and methods: a broad...