Hydrazides are important starting materials for a wide range of derivatives, utilizable as potential pharmaceutical products for human use. Over 70% of recently reported syntheses of hydrazide derivatives were evaluated for antimicrobial and or antifungal activity in preclinical studies. The synthesis, biological activities, and applications of hydrazone and hydrazide derivatives were reported by many research groups. Antibacterial agents have saved many lives and helped the growth of modern medicine over the past half century. The emergence of drug resistance jeopardizes is the effectiveness...