It is evident that thiazolopyrimidine derivatives serve as the auspicious and effective research area with a bright future and serve as the inspiration for future molecular planning.The literature survey revealed that thiazolopyrimidine derivatives possessed diverse biological activities and therapeutic potentials, easier and novel synthetic routes for synthesis, have been taken into considerable attention to scientists, researchers and pharmacologists.

This study is an attempt to explore the quality of generic versus branded drugs. This study has once again dispelled the myth that "only the costly drugs are more effective" and highlights the need of all stakeholders to promote the use of generic drugs in India as well as in other countries. we concluded that the branded products and their counterparts, branded generic products, conformed to the statutory quality standards laid down under the Indian laws [Drugs and cosmetics act, 1940 and rules, 1945]. In addition, no difference in their quality was noted, irrespective of the fact that they...

Parkinson's disease is a neurodegenerative illness that is frequently associated with motor symptoms such as bradykinesia, stiffness, resting tremor, and postural instability. Based on clinical characteristics and the patient's reaction to dopamine medication, it is usually diagnosed in the sixth or seventh decade of life. Although the precise etiology is still unknown, it is most likely the result of a genetic and environmental cocktail that kills dopamine-producing neurons in the substantia nigra.

La maladie de Parkinson est une maladie neurodégénérative fréquemment associée à des symptômes moteurs tels que la bradykinésie, la rigidité, les tremblements au repos et l'instabilité posturale. Sur la base des caractéristiques cliniques et de la réaction du patient aux médicaments dopaminergiques, la maladie est généralement diagnostiquée au cours de la sixième ou de la septième décennie de la vie. Bien que l'étiologie précise soit encore inconnue, la maladie est très probablement le résultat d'un cocktail génétique et environnemental qui tue les neurones...

Die Parkinson-Krankheit ist eine neurodegenerative Erkrankung, die häufig mit motorischen Symptomen wie Bradykinesie, Steifheit, Ruhetremor und Haltungsinstabilität einhergeht. Aufgrund der klinischen Merkmale und der Reaktion des Patienten auf Dopaminmedikamente wird die Krankheit in der Regel im sechsten oder siebten Lebensjahrzehnt diagnostiziert . Obwohl die genaue Ätiologie noch unbekannt ist, ist sie höchstwahrscheinlich das Ergebnis eines genetischen und umweltbedingten Cocktails, der dopaminproduzierende Neuronen in der Substantia nigraabtötet .

Lisinopril is an antihypertensive agent indicated for the prevention of hypertension, acute myocardial infarction and diabetic nephropathy. It is an angiotensin converting enzyme(ACE) inhibitor. It has a short half-life and undergoes variable first pass metabolism. It is required to be administered two or three times daily which results in poor patient compliance. In this work an attempt was made to formulate & evaluate TDDS for sustained release of lisinopril by solvent evaporation method. Low molecular weight, good permeability and shorter half-life of the drug made it a suitable candidate...

The incidence of systemic microbial infections has increased severely due to the increase of immunocompromised hosts.In the present study, a novel series of Indole based Thiazolidinone derivatives were synthesized and evaluated for their in vitro antimicrobial activity. The entire synthesized compounds were confirmed by IR and 1HNMR spectroscopy study and all physicochemical properties. Compounds below are the most active compounds having antimicrobial activity.