Sahbani, Amani, Ben Cheikh, Mohamed Hedi, Kraiem, Jamil
The aim of this project was to assess the pharmaceutical quality of 5 batches of paracetamol synthesized according to green chemistry principles, in compliance with European Pharmacopoeia requirements. These batches were characterized by qualitative and quantitative analyses: chromatography, infrared spectroscopy and differential scanning calorimetry. The most compliant batches were subjected to stability tests and forced degradation tests. Analyses confirmed the identity of the paracetamol synthesized, with FTIR correlations > 98%. HPLC-DAD purities were as high as 77.3%, and the batches...
The aim of this project was to assess the pharmaceutical quality of 5 batches of paracetamol synthesized according to green chemistry principles, in c...