Regeneration of tissues rather than replacement with artificial substitutes is an emerging and exciting field in the health sciences. Previously endodontic treatment concepts were based on the removal of inflamed or necrotic pulp tissue and replacement by a synthetic biomaterial/Root canal treatments. However, the traditional RCT have their own drawbacks and maybe related with a certain risk of failure. Excessive tooth tissue cutting in RCT and loss of vitality may lead to insufficient tooth resistance, resulting in the occurrence of tooth fracture.[2] With the development of oral materials...