Various clinical manifestations are observed in humans with altered metabolim, which are also manifested in oral cavity. Many of the disorders are manifested mainly in the tongue causing various appearances such as macroglossia as seen in acromegaly, hypothyroidism, hyperpituitarism, mucopolysaccharidoses, abnormal melanin pigmentation as seen in Addison's disease, decreased two point discrimination as reported in a case of Cushings syndrome, sore tongue and changes in taste perception are reported in diabetes mellitus.In some other metabolic disturbances, only a part of the tongue is...

This comprehensive manual provides an in-depth exploration of tissue fixation, processing, and embedding techniques essential in histopathology and biomedical research. Beginning with the fundamental concepts of autolysis and fixation, the book delves into the chemistry and classification of various fixatives including aldehydes, oxidizing agents, protein denaturants, and cross-linking compounds highlighting their mechanisms, applications, and impact on tissue morphology and staining properties. It further addresses the physical and chemical factors affecting fixation, such as pH,...