Liver cirrhosis is accompanied by a variety of severe complications that drastically reduce patients' life expectancy. The aim of this study was to improve therapeutical interventions for liver cirrhosis patients by identifying patients with a high need for treatment and by characterizing the pathophysiological changes in cirrhosis patients to facilitate drug development and pharmacotherapy.A hallmark of disease progression in liver cirrhosis is the transition from a compensated to a decompensated state. While patients are mostly asymptomatic in the compensated state, the decompensated stage...