Cancer's lethality and the shortcomings of current treatments propel the urgency for effective alternatives. Lung Cancer, a leading cause of malignancy-related deaths, is exacerbated by widespread smoking. Decades of research into cancer biology aim to enhance therapeutic efficacy while minimizing side effects. The Unfolded Protein Response (UPR) pathway, pivotal in maintaining protein homeostasis and responding to ER stress, garners significant interest. The molecular chaperone GRP78, integral in cellular processes during ER stress, holds a multifaceted role in lung cancer biology,...