The current study was designed to evaluate Epstein-Barr virus and its relationship to periodontal pathogens in individuals with periodontitis. Our knowledge of the infectious causes of periodontal disease, particularly the interplay between the herpesvirus, bacteria, and host immune system in severe periodontitis, has advanced significantly. This idea may assist to elucidate the pathophysiology of periodontitis. Periodontal herpesvirus-bacteria coinfections may share pathogenic properties with related coinfections in systemic disorders. New strategies for the treatment of destructive...