The main objective of the research is to design an active thiol substituted oxadiazole inhibitor against GlmS receptor of gram-negative and gram-positive bacteria with in silico and in vitro antibacterial approaches. A scaffold of 1,3,4-oxadiazole was designed and the synthetic feasibility to attain the scaffold. PyRx software was used. The ligand poses with the least free energy. ADMET studies were conducted. The synthesis steps included 4 different reactions. Substituted carboxylic acids were used as the starting reagent. All of the reactions were monitored by TLC. Synthesized compounds...

Le criblage phytochimique de l'extrait brut a révélé la présence de flavonoïdes et de composés polyphénoliques comme constituants majeurs. Les composés polyphénoliques, y compris les tanins, présentent une activité anthelminthique. Les tanins présents dans l'extrait d'Elephantopus Scaber peuvent produire des effets similaires. Un autre mécanisme anthelminthique potentiel des tanins consiste à se lier à des protéines libres dans le tractus gastro-intestinal de l'animal hôte ou à des glycoprotéines sur la cuticule du parasite, ce qui entraîne la mort de ce dernier.L'extrait...

In this phytochemical characterization of Cinnamomum malabatrum seeds for their biological properties. The preliminary phytochemical evaluation of Cinnamomum malabatrum leaves revealed the presence of alkaloids, volatile oils, phenolic compounds, tannins and triterpinoids. The extract was screened to analyse the antimicrobial and antioxidant activity; thus the extract exhibits an immense remarkable effect. The extract showed the presence of the total alkaloid content by comparing with the standard strychnine hydrochloride in UV-Vis spectrophotometric method. The extract inhibits thye growth...