Adhesion of the knee is a major concern after knee surgery, the treatment of which is difficult. Botulinum toxin A (BTX-A) injection is demonstrated as efficient in treating knee adhesion after surgery. However, the treatment outcomes and the mechanism of action are not yet determined. The formation of adhesion in the knee is a common complication after knee surgery. The rate of arthrofibrosis following total knee arthroplasty (TKA) is estimated to be 8-12% and the rate after ligament reconstruction is 0-4%, and it is up to 7% following a fracture of the tibial plateau high-energy fractures....