Connexins constitutes a family of structurally related transmembrane proteins that connect two adjacent cells by forming gap junctions. Connexins are multi- functional proteins with diverse role in the cell physiology. Connexin 43 is an important gap junction protein in vertebrates and is known for its tumor suppressive properties. Connexin 43 plays an important role in the regulation of cell growth, differentiation and is important for maintainance of tissue homeostasis. Cx43 is abundantly expressed in the human intestinal epithelial cells and muscularis mucosae. Therefore, loss of Cx43...