Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate. . In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drug compounds. In fact, the most popular approach is the incorporation of the drug compound into inert lipid...
Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability...
In the winter of 1951, a storyteller arrives at the home of nine-year-old Ronan OMara in the Irish countryside. The last practitioner of an honored, centuries-old tradition, the Seanchai enthralls his assembled audience for three evenings running with narratives of foolish kings and fabled saints, of enduring accomplishments and selfless acts -- until he is banished from the household for blasphemy and moves on. But these three incomparable nights have changed young Ronan forever, setting him on the course he will follow for years to come -- as he persues the elusive, itinerant story teller...
In the winter of 1951, a storyteller arrives at the home of nine-year-old Ronan OMara in the Irish countryside. The last practitioner of an honored, c...
