In order to investigate how many species of Mycoplasma are causing the disease/s in goats in Pakistan, 12 districts have been probed to characterize caprine Mycoplasmas species. Isolation, identification and confirmation of the etiological agent/s of caprine Mycoplasmosis has been performed by using culturing, bio-chemical and polymerase chain reaction tests.Saponin inactivated vaccine from field isolate of Mycoplasma mycoides subspecies capri, was prepared and evaluated in experimental goats. M. ovipneumoniae induced a strong in-vitro polyclonal suppression of CD4+, CD8+ and B blood...