Antibiotics are secondary metabolites produced by microorganisms, extremely important to the health of our society. Cephalosporins are broad-spectrum antibiotics which are very similar in structure and action to penicillins but more resistant to - lactamases. Optimization of media is useful to increase the production of antibiotics. Induction of mutation is commonly employed to increase the yield of secondary metabolites like antibiotics. Chemical mutation is preferred method because of the ease in handling and avoiding the hazardous effects of radiations. Usually, mutations are induced in...