Paratuberculosis (Johnes disease) is a chronic infectious, granulomatous enteric disease of domestic and wild ruminants caused by Mycobacterium avium subsp. paratuberculosis (Map). To date, no effective prophylactic candidates are available for early protection against the paratuberculosis infection in animals. Numerous secretory proteins Map have shown to be potent immunogens and can be used as subunit vaccines/DNA vaccine and also can be used as a specific detection .This book, therefore provides a novel antigen family protein of Map, PPE (proline-proline-glutamic acid rich) ...