The objectives of this work is comparing three different kinds of sulfonamide compounds by evaluating structure modification through their examination towards more important properties such as: (a) Surface properties of the synthesized sulfonamide compounds were studied through surface parameters cmc, (cmc), A(min) and (max). Most of these tested compounds have remarkable surface activity. (b) The target compounds were tested to determine structure-biological activity relationship against different types of pathogenic bacterial species. The amine acid salts of bis (2-aminophenyl)...