"Optimal Observation for Cyber-physical Systems" addresses the challenge, fundamental to the design of wireless sensor networks (WSNs), presented by the obligatory trade-off between precise estimates and system constraints. A unified theoretical framework, based on the well-established theory of optimal experimental design and providing consistent solutions to problems hitherto requiring a variety of approaches, is put forward to solve a large class of optimal observation problems. The Fisher information matrix plays a key role in this framework and makes it feasible to provide analytical...