This volume collects the notes of the CIME course "Nonlinear PDE's and applications" held in Cetraro (Italy) on June 23-28, 2008. It consists of four series of lectures, delivered by Stefano Bianchini (SISSA, Trieste), Eric A. Carlen (Rutgers University), Alexander Mielke (WIAS, Berlin), and Cedric Villani (Ecole Normale Superieure de Lyon). They presented a broad overview of far-reaching findings and exciting new developments concerning, in particular, optimal transport theory, nonlinear evolution equations, functional inequalities, and differential geometry. A sampling of the main topics...