Therapeutic immunosuppression has very broad applications in clinicalmed icine, ranging from prevention and treatment of organ and bone marrow transplant rejection, management of various autoimmune disorders (e. g. rheumatoid arthritis) skin disease, and asthma. Whereas traditionally, only a small repertoire of immunosuppressive agents was available for clinical use, recent discoveries have significantly increasedthe number ofapproved agents, resulting in numerous trials to further evaluate their potential. In addition, products of the biotechnology industry, - monoclonal antibodies,...