W. Arber, W. Braun, F. Cramer, R. Haas, W. Henle, P. H. Hofschneider, N. K. Jerne, P. Koldovsky, H. Koprowski, O. Maaløe
The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type. A. The Herpesviruses A consideration of the genetic analysis of members of the herpesvirus...
The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reas...
W. Arber, W. Braun, F. Cramer, R. Haas, W. Henle, P. H. Hofschneider, N. K. Jerne, P. Koldovsky, H. Koprowski, O. Maaløe
Immunoglobulin gene expression appears to include a number of unique features (Cohn, 1971; Gaily and Edelman, 1972; Hood et aI., 1975). First, a variety of genetic and protein structural evidence suggests that two discrete genes - both a variable region gene and a constant region gene - specify each heavy chain and each light chain. This constitutes the twogene-one polypeptide hypothesis. Second, a single differentiated lymphocyte or plasma cell appears to express only one heavy chain allele and one light chain allele at a time. This is the only example of allelic exclusion known in mammalian...
Immunoglobulin gene expression appears to include a number of unique features (Cohn, 1971; Gaily and Edelman, 1972; Hood et aI., 1975). First, a varie...
W. Arber, W. Braun, F. Cramer, R. Haas, W. Henle, P. H. Hofschneider, N. K. Jerne, P. Koldovsky, H. Koprowski, O. Maaløe
The study of the genetic regulation of immune response to natural multidetermi- nant immunogens was undertaken by the method of bidirectional selective breed- ing of High or Low antibody responder lines of mice. Five Selections are described: Selection I, carried out for agglutinin responsiveness to sheep erythrocytes and pigeon erythrocytes alternated in each generation. Selection II, carried out for agglutinin responsiveness to sheep erythrocytes repeated in each generation. Selection III and Selection IV performed respectively for agglutinin response to flagellar or somatic antigens of...
The study of the genetic regulation of immune response to natural multidetermi- nant immunogens was undertaken by the method of bidirectional selectiv...
